FM04

Research use only, not for human use.

FM04 is an orally active and highly potent inhibitor of P-glycoprotein (P-gp) with an EC50 value of 83 nM. FM04 can interact with Q1193 and I1115 in human P-gp nucleotide binding domain 2 (NBD2).

FM04 is a potent P-glycoprotein (P-gp) inhibitor (EC50=83 nM). FM04 inhibits P-gp in 2 mechanism: (1)FM04 binds to Q1193, followed by interacting with the functionally critical residues H1195 and T1226; or (2)FM04 binds to I1115 (a functionally critical residue itself), disrupting the R262-Q1081-Q1118 interaction pocket and uncoupling ICL2-NBD2 interaction and thereby inhibiting P-gp.

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Others

Other Targets

P-gp

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1807320-40-6

415.48

C26H25NO4

>98% (HPLC)

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O=C1C=C(OC=2C1=CC=CC2)C3=CC=C(OCCOCCNCC4=CC=CC=C4)C=C3

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(-20℃)

With Ice Pack

≥ 2 years