Cart
sales@molnova.com
WDR5-0102
CAS No. 824960-50-1
WDR5-0102( —— )
Catalog No. M36105 CAS No. 824960-50-1
WDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 215 | In Stock |
|
| 5MG | 163 | In Stock |
|
| 10MG | 275 | In Stock |
|
| 25MG | 549 | In Stock |
|
| 50MG | 775 | In Stock |
|
| 100MG | 1070 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2130 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameWDR5-0102
-
NoteResearch use only, not for human use.
-
Brief DescriptionWDR5-0102 is a compound that inhibits the WDR5-MLL1 interface (K dis = 7 μM, K d = 4 μM), selectively reducing MLL1 HMT activity without affecting the human H3K4 methyltransferase SETD7 or other HMTs, including G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5.
-
DescriptionWDR5-0102 is an inhibitor targeting WDR5-MLL1 interface (Kdis=7 μM, Kd=4 μM). WDR5-0102 suppresses MLL1 HMT activity, but not human H3K4 methyltransferase SETD7 and six other HMTs: G9a, EHMT1, SUV39H2, SETD8, PRMT3, and PRMT5.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorHistone Methyltransferase
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number824960-50-1
-
Formula Weight374.82
-
Molecular FormulaC18H19ClN4O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 50 mg/mL (133.40 mM; Ultrasonic (<60°C)
-
SMILESN(C(=O)C1=C(Cl)C=CC=C1)C2=C(C=CC(N(=O)=O)=C2)N3CCN(C)CC3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ye X, et al. The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening. Bioorg Med Chem Lett. 2019 Feb 15;29(4):638-645. ?
molnova catalog
related products
-
Dihydroguaiaretic ac...
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress.
-
Neuropeptide W-30 (h...
Neuropeptide W-30 (human) is an important stress mediator in the central nervous system that modulates the hypothalamus-pituitary-adrenal (HPA) axis and sympathetic outflow. Neuropeptide W-30 (human) is an endogenous ligand for the two structurally related orphan G-protein-coupled receptors (GPCRs) GPR7 and GPR8. Neuropeptide W-30 (human)activates and binds to both GPR7 and GPR8 at similar effective doses.
-
NS13001
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels).
