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Ampreloxetine hydrochloride
CAS No. 1227056-87-2
Ampreloxetine hydrochloride( —— )
Catalog No. M36095 CAS No. 1227056-87-2
Ampreloxetine hydrochloride (TD-9855 HCl) has anti-inflammatory activity and is a potential compound for the treatment of depression and Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 187 | In Stock |
|
| 10MG | 306 | In Stock |
|
| 25MG | 520 | In Stock |
|
| 50MG | 733 | In Stock |
|
| 100MG | 1004 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2027 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAmpreloxetine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAmpreloxetine hydrochloride (TD-9855 HCl) has anti-inflammatory activity and is a potential compound for the treatment of depression and Alzheimer's disease.
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DescriptionAmpreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT). Ampreloxetine hydrochloride binds norepinephrine transporters (NET) and serotonin transporters (SERT) with EC50 values of 11.7 ng/mL and 50.8 ng/mL, respectively, in plasma.
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In Vitro——
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In VivoAnimal Model:RatDosage:0.3, 1, 5, 10, 30, and 60mg/kg Administration:PO; euthanized by decapitation at 0.5, 2, 4, 6, and 8 hr for 5mg/ kg dose level; 2 hr for 0.3, 1, 10, 30, and 60mg/kg dose levels Result:In the effect compartment PK/PD analysis for NET and SERT occupancy, the estimated EC50 for occupancy was 11.7ng/mL for NET and 50.8ng/mL for SERT in rat spinal cords, and the projected human plasma EC50 values were 5.5ng/mL for NET and 23.9ng/mL for SERT.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number1227056-87-2
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Formula Weight357.8
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Molecular FormulaC18H19ClF3NO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (279.49 mM; Ultrasonic )
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SMILESCl.FC=1C=C(F)C(OCC=2C=CC=CC2C3CCNCC3)=C(F)C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Smith JA, et al. Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor. Int J Neuropsychopharmacol. 2014 Dec 13;18(2):pyu027. ?
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