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SRD5A1-IN-1
CAS No. 2279077-93-7
SRD5A1-IN-1( —— )
Catalog No. M36063 CAS No. 2279077-93-7
SRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 μM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 150 | In Stock |
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| 5MG | 136 | In Stock |
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| 10MG | 198 | In Stock |
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| 25MG | 320 | In Stock |
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| 50MG | 434 | In Stock |
|
| 100MG | 551 | In Stock |
|
| 200MG | 728 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSRD5A1-IN-1
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NoteResearch use only, not for human use.
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Brief DescriptionSRD5A1-IN-1 is an inhibitor of steroid 5α-reductase type 1 (SRD5A1, IC50 = 1.44 μM).
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DescriptionSRD5A1-IN-1 (Compound 4) is a competitive and covalent steroid 5α-reductase type 1 (SRD5A1) inhibitor with an IC50 of 1.44 μM. SRD5A1-IN-1 modulates SRD5A1 function, leading to a lower level of dihydrotestosterone (DHT) production and SRD5A1 protein suppression.
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In VitroWestern Blot Analysis Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 hResult:Showed a significant decrease in SRD5A1 protein expression at 1 and 2.5 μM at 24 h, whereas there were no significant changes in the level of SRD5A1 protein at 12 h.RT-PCR Cell Line:HaCaT Concentration:0.5, 1, and 2.5 μM Incubation Time:12 h and 24 h Result:Did not affect the mRNA expression of SRD5A1 at both incubation times.Cell Cytotoxicity Assay Cell Line:HaCaT Concentration:0.2, 0.5, 1, and 2.5 μM Incubation Time:24 h Result:Displayed no significant cytotoxicity (IC50: 29.99?±?8.69 μM).
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2279077-93-7
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Formula Weight391.27
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Molecular FormulaC17H11F6NO3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (255.58 mM; Ultrasonic )
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SMILESN(C(/C=C/C1=CC(O)=C(O)C=C1)=O)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lin A C K, et al. Caffeic acid N-[3, 5-bis (trifluoromethyl) phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics. Scientific Reports, 2022, 12(1): 1-20.
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