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TH1760
CAS No. 2567914-01-4
TH1760( —— )
Catalog No. M36034 CAS No. 2567914-01-4
TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 48 | In Stock |
|
| 10MG | 86 | In Stock |
|
| 25MG | 193 | In Stock |
|
| 50MG | 366 | In Stock |
|
| 100MG | 533 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTH1760
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NoteResearch use only, not for human use.
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Brief DescriptionTH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM).
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DescriptionTH1760 is an inhibitor of NUDIX-type 15 (NUDT15) with an IC50 value of 25 nM. TH1760 sensitizes cells to 6-thioguanine by enhancing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 enhances the anti-leukemia effect of thiopurine.
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In VitroWestern Blot Analysis Cell Line:HCT116 cells.Concentration:10 μM.Incubation Time:4 h.Result:Inhibited the expression of NUDT15.Western Blot Analysis Cell Line:AML HL-60 cells.Concentration:10 μM.Incubation Time: 3 h.Result:Significantly inhibited the expression of NUDT15 when the temperature was higher than 54℃.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorNUDIX hydrolase
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Research Area——
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Indication——
Chemical Information
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CAS Number2567914-01-4
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Formula Weight426.45
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Molecular FormulaC20H18N4O5S
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Purity>98% (HPLC)
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Solubility——
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SMILESS(=O)(=O)(C=1C=C2C(=CC1)NC(=O)O2)N3CCN(C(=O)C=4C=C5C(=CC4)NC=C5)CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang SM, et al. Development of a chemical probe against NUDT15. Nat Chem Biol. 2020 Oct;16(10):1120-1128. ?
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