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C004019
CAS No. 2417159-57-8
C004019( —— )
Catalog No. M36015 CAS No. 2417159-57-8
C004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 613 | In Stock |
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| 10MG | 896 | In Stock |
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| 25MG | 1311 | In Stock |
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| 50MG | 1748 | In Stock |
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| 100MG | 2353 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameC004019
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NoteResearch use only, not for human use.
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Brief DescriptionC004019 is a small molecule PROTAC capable of targeting tau for selective protein degradation from the cell, while recruiting tau and E3 ligase (Vhl) for selective enhancement of tau ubiquitination and proteollyzation. C004019 is a candidate for AD and related tau protein diseases.
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DescriptionC004019 is a small-molecule PROTAC. C004019 simultaneously recruites tau and E3-ligase (Vhl) and thus selectively enhances ubiquitination and proteolysis of tau proteins. C004019 can be used for Alzheimer disease (AD) research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPROTACs | Microtubule Associated
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Research Area——
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Indication——
Chemical Information
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CAS Number2417159-57-8
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Formula Weight1035.29
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Molecular FormulaC49H70N12O9S2
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Purity>98% (HPLC)
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Solubility——
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SMILESN(CC(NCCOCCOCCOCC(N[C@H](C(=O)N1[C@@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](O)C1)C(C)(C)C)=O)=O)(C)C4=NC(=NC(NCCC5=CC=CS5)=N4)N6CCN(C(C)=O)CCC6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Aminoadipic acid
Aminoadipic acid (2-aminoadipate) is a metabolite in the principal biochemical pathway of lysine. It is an intermediate in the metabolism of lysine and saccharopine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor N-methyl-D-aspartate (NMDA).
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PTD-p65-P1 Peptide
PTD-p65-P1 Peptide is a nuclear transcription factor NF-kappaB inhibitor, composed of a membrane-translocating peptide sequence generated from antennapedia (PTD) conjugated with p65-P1, which selectively inhibits activation induced by various inflammatory stimuli. PTD-p65-P1 suppressed NF-kappaB activation induced by lipopolysaccharide, interleukin-1, okadaic acid, phorbol 12-myristate 13-acetate, H(2)O(2), and cigarette smoke condensate as well as that induced by TNF.
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S- (+)-Rolipram
S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
