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IMS2186

CAS No. 1031206-36-6

IMS2186( —— )

Catalog No. M35954 CAS No. 1031206-36-6

IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 29 In Stock
10MG 39 In Stock
25MG 90 In Stock
50MG 131 In Stock
100MG 193 In Stock
200MG 275 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    IMS2186
  • Note
    Research use only, not for human use.
  • Brief Description
    IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects.
  • Description
    IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells.
  • In Vitro
    Cell Cycle Analysis Cell Line:Cancer H460 cells Concentration:3 μM, 10 μM Incubation Time:Result:Showed anti-proliferative activity mediated by arresting cell cycle at G2/M.
  • In Vivo
    Animal Model:Rat model of laser induced CNV Dosage:100 μg/eye, 2.0 μL of the solution of 50 μg/μL Administration:Intravitreal injection; single dose Result:Resulted 30% reduction of lesion area compared to PBS in the lesion area measurement.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1031206-36-6
  • Formula Weight
    296.32
  • Molecular Formula
    C18H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 66.67 mg/mL (224.99 mM; Ultrasonic )
  • SMILES
    COc1ccc(\C=C2/COc3ccc(C)cc3C2=O)cc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Falkenstein IA, et al. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul;33(7):599-609.?
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