Cart
sales@molnova.com
Home - Products - Others - Other Targets - IMS2186

IMS2186

CAS No. 1031206-36-6

IMS2186( —— )

Catalog No. M35954 CAS No. 1031206-36-6

IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 36 Get Quote
10MG 55 Get Quote
25MG 125 Get Quote
50MG 186 Get Quote
100MG 266 Get Quote
200MG 381 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    IMS2186
  • Note
    Research use only, not for human use.
  • Brief Description
    IMS2186 is a reagent with activity of antichoroidal neovascularization (CNV). IMS2186 could arrest cancer cell cycle in G2/M phase, result in exerting anti-proliferation and anti-angiogenesis effects.
  • Description
    IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells.
  • In Vitro
    Cell Cycle Analysis Cell Line:Cancer H460 cells Concentration:3 μM, 10 μM Incubation Time:Result:Showed anti-proliferative activity mediated by arresting cell cycle at G2/M.
  • In Vivo
    Animal Model:Rat model of laser induced CNV Dosage:100 μg/eye, 2.0 μL of the solution of 50 μg/μL Administration:Intravitreal injection; single dose Result:Resulted 30% reduction of lesion area compared to PBS in the lesion area measurement.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1031206-36-6
  • Formula Weight
    296.32
  • Molecular Formula
    C18H16O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 66.67 mg/mL (224.99 mM; Ultrasonic )
  • SMILES
    COc1ccc(\C=C2/COc3ccc(C)cc3C2=O)cc1O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Falkenstein IA, et al. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul;33(7):599-609.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • 5-amino-2-(2,6-dioxo...

    5-amino-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione is a E3 ligase ligand used in PROTAC technology.

  • MK-0159

    MK-0159 is an orally available, highly potent CD38 inhibitor with myocardial injury protection for the study of cardiac ischemia and reperfusion injury.

  • PF-543

    PF-543, a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.

Sign In Join Free