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UCM-1306
CAS No. 2258608-78-3
UCM-1306( —— )
Catalog No. M35941 CAS No. 2258608-78-3
UCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 159 | In Stock |
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| 50MG | 230 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameUCM-1306
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NoteResearch use only, not for human use.
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Brief DescriptionUCM-1306 is a potent and orally active allosteric modulator (PAM) of the human dopamine D1 receptor. It increases the maximal effect of endogenous dopamine (DA) in both human and mouse D1 receptors.
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DescriptionUCM-1306 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson’s disease (PD).
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In Vitro——
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In VivoAnimal Model:Adult C57BL/6J mice with cocaine-induced hyperactivity model Dosage:1 mg/kg; cocaine (20 mg/kg, sc) Administration:Intraperitoneal injection Result:Increased cocaine-induced hyperlocomotion, suggesting an in vivo potentiation of DA action at the D1R.Animal Model:Adult C57BL/6J mice Dosage:1 mg/kg Administration:Intraperitoneal injection Result:Increased memory trace in C57BL/6J mice.
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Synonyms——
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PathwayGPCR/G Protein
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TargetDopamine Receptor
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RecptorDopamine Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2258608-78-3
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Formula Weight279.33
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Molecular FormulaC14H14FNO2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (179.00 mM; Ultrasonic )
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SMILESCS(=N)(=O)c1ccc(cc1)-c1ccccc1OCF
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. García-Cárceles J, et, al. 2-(Fluoromethoxy)-4'-(S-methanesulfonimidoyl)-1,1'-biphenyl (UCM-1306), an Orally Bioavailable Positive Allosteric Modulator of the Human Dopamine D1 Receptor for Parkinson's Disease. J Med Chem. 2022 Sep 22;65(18):12256-12272.?
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