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Thiolutin
CAS No. 87-11-6
Thiolutin( —— )
Catalog No. M35936 CAS No. 87-11-6
Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 185 | In Stock |
|
| 5MG | 282 | In Stock |
|
| 10MG | 464 | In Stock |
|
| 25MG | 881 | In Stock |
|
| 50MG | 1224 | In Stock |
|
| 100MG | 1611 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameThiolutin
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NoteResearch use only, not for human use.
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Brief DescriptionThiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.
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DescriptionThiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntibiotic
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RecptorAntibiotic | Antibacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number87-11-6
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Formula Weight228.29
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Molecular FormulaC8H8N2O2S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 6.25 mg/mL (27.38 mM; Ultrasonic (<60°C)
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SMILESCC(=O)Nc1c2sscc2n(C)c1=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.?
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