Cart
sales@molnova.com
Thiolutin
CAS No. 87-11-6
Thiolutin( —— )
Catalog No. M35936 CAS No. 87-11-6
Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 319 | In Stock |
|
| 2MG | 185 | In Stock |
|
| 5MG | 282 | In Stock |
|
| 10MG | 464 | In Stock |
|
| 25MG | 881 | In Stock |
|
| 50MG | 1224 | In Stock |
|
| 100MG | 1611 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameThiolutin
-
NoteResearch use only, not for human use.
-
Brief DescriptionThiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly.
-
DescriptionThiolutin (Acetopyrrothin) is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Thiolutin inhibits the JAMM metalloproteases Csn5, Associated-molecule-with-the-SH3-Domain-of-STAM (AMSH) and Brcc36. Thiolutin is a potent and selective inhibitor of endothelial cell adhesion accompanied by rapid induction of Heat-shock protein beta-1 (Hsp27) phosphorylation.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayMicrobiology/Virology
-
TargetAntibiotic
-
RecptorAntibiotic | Antibacterial
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number87-11-6
-
Formula Weight228.29
-
Molecular FormulaC8H8N2O2S2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 6.25 mg/mL (27.38 mM; Ultrasonic (<60°C)
-
SMILESCC(=O)Nc1c2sscc2n(C)c1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Lauinger L, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nat Chem Biol. 2017 Jul;13(7):709-714.?
molnova catalog
related products
-
Bekanamycin
Bekanamycin is an aminoglycoside antibiotic.
-
Ertapenem sodium
Ertapenem sodium is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases.
-
Cephalexin monohydra...
Cephalexin monohydrate (Cephalexin hydrate) is an orally available semi-synthetic cephalosporin antibiotic with significant antimicrobial activity that inhibits bacterial proliferation by targeting penicillin-binding proteins (PBPs).
