Deoxyribonuclease I

Research use only, not for human use.

Deoxyribonuclease I (DNase I) is an enzyme commonly used to purify proteins with potential anti-inflammatory and anticancer activity and can be used to study bacterial and fungal infections.

DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer.

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Deoxyribonuclease (0.1 U; i.p.; once daily for 3 days) inhibits liver metastasis, besides results in a greater prolongation of the survival period by combining surgical removal of the primary tumour mass.Animal Model: Female BALB/c x DBA/2 mice with murine tumour L5178Y-ML cells subcutaneous injection Dosage:0.1 U per mouse Administration:Intravenous injection; 0.1 U; once daily for three days Result:Reduced liver weight from 2.26 to 1.55 g, affected the intensity of liver metastasis, reduced the numbers and sizes of metastatic and affected tumour cell arrest.Animal Model:Female BALB/c x DBA/2 mice with murine tumour and surgical removal of subcutaneous tumours Dosage:0.1 U per mouse Administration:Intravenous injection; 0.1 U; once daily for 3 days either before or after primary tumour removal Result:Significantly prolongated survival after tumour cell inoculation compared to the untreated group.

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Others

Other Targets

Others

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9003-98-9

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>98% (HPLC)

In Vitro:?DMSO : 43.48 mg/mL (adjust pH to 3 with 1M HCl)

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(-20℃)

With Ice Pack

≥ 2 years