Anti-inflammatory agent 35( —— )

Catalog No. M35802 CAS No. 2293951-00-3

Anti-inflammatory agent 35 is a potent anti-inflammatory agent.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
5MG	36	Get Quote
10MG	55	Get Quote
25MG	109	Get Quote
50MG	183	Get Quote
100MG	290	Get Quote
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Biological Information

Product Name

Anti-inflammatory agent 35
Note

Research use only, not for human use.
Brief Description

Anti-inflammatory agent 35 is a potent anti-inflammatory agent.
Description

Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo.
In Vitro

Western Blot Analysis Cell Line:RAW 264.7 mouse macrophages Concentration:10 μM Incubation Time:30 min; followed by incubation with 0.5 μg/mL LPS for another 30 min Result:Decreased the phosphorylation of p38 and ERK. And down-regulated IκB (inhibitor of NF-κB), inhibits the transcription of TNF-α, IL-6, IL-1β, ICAM-1.
In Vivo

Animal Model:ALI mouse model (C57BL/6 mice)Dosage:10 mg/kg Administration:Intraperitoneal injection, once daily for 1 week; 30 min later every dose, followed by 5 mg/kg LPS, intratracheal injection Result:Significantly normalized the wet/dry ratio of lungs.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Immunology/Inflammation related
Research Area

——
Indication

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Chemical Information

CAS Number

2293951-00-3
Formula Weight

495.52
Molecular Formula

C27H29NO8
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 16.67 mg/mL (33.64 mM; Ultrasonic (<60°C)
SMILES

COc1cc(\C=C\C(=O)N2CCC\C(=C/c3cc(OC)c(OC)c(OC)c3)C2=O)ccc1OC(C)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Qian J, et al. Design and synthesis novel di-carbonyl analogs of curcumin (DACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI). Eur J Med Chem. 2019 Apr 1;167:414-425. ?

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