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CSF1R-IN-3
CAS No. 2760584-90-3
CSF1R-IN-3( —— )
Catalog No. M35761 CAS No. 2760584-90-3
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 326 | In Stock |
|
| 5MG | 258 | In Stock |
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| 10MG | 377 | In Stock |
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| 25MG | 701 | In Stock |
|
| 50MG | 1004 | In Stock |
|
| 100MG | 1442 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCSF1R-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionCSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells.
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DescriptionCSF1R-IN-3 (compound 21) is a potent and orally active CSF-1R inhibitor (IC50=2.1 nM). CSF1R-IN-3 is a potent antiproliferative activity against colorectal cancer cells. CSF1R-IN-3 inhibits the progression of colorectal cancer by suppressing the migration of macrophages, reprograming M2-like macrophages to the M1 phenotype, and enhancing the antitumor immunity.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayTyrosine Kinase
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TargetCSF1R
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Recptorc-Fms | CSF-1R
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Research Area——
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Indication——
Chemical Information
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CAS Number2760584-90-3
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Formula Weight574.67
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Molecular FormulaC30H38N8O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (108.76 mM; Ultrasonic (<60°C)
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SMILESCN1CCN(CC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4cc(NC(=O)Nc5cc(on5)C(C)(C)C)ccc34)c2C)CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lv Q, et al. Discovery of (Z)-1-(3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-3-(isoxazol-3-yl)urea Derivatives as Novel and Orally Highly Effective CSF-1R Inhibitors for Potential Colorectal Cancer Immunotherapy. J Med Chem. 2021;64(23):17184-17208. ?
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