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PCLX-001

CAS No. 1215011-08-7

PCLX-001( —— )

Catalog No. M35742 CAS No. 1215011-08-7

PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 250 In Stock
5MG 211 In Stock
10MG 316 In Stock
25MG 548 In Stock
50MG 762 In Stock
100MG 1070 In Stock
200MG 1442 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PCLX-001
  • Note
    Research use only, not for human use.
  • Brief Description
    PCLX-001 is a small-molecule compound that acts as an orally active inhibitor of N-myristoyltransferase (NMT), specifically targeting NMT1 and NMT2 with IC50 values of 5 nM and 8 nM, respectively.
  • Description
    PCLX-001 is an orally acitve, small-molecule, dual N-myristoyltransferase (NMT) inhibitor, with IC50s of 5 nM (NMT1) and 8 nM (NMT2), respectively. PCLX-001 exhibits anti-tumor activity and inhibits early B-cell receptor (BCR) signaling, can be used to B-cell malignancies research.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1215011-08-7
  • Formula Weight
    537.51
  • Molecular Formula
    C24H30Cl2N6O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 10 mg/mL (18.60 mM; Ultrasonic (<60°C)
  • SMILES
    N(S(=O)(=O)C1=C(Cl)C=C(C=C1Cl)C=2C=C(N=CC2)N3CCNCC3)C=4C(CC(C)C)=NN(C)C4C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Michael Weickert, et al. Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies. Blood. 2019. 134(s1):3362.
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