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KS106

CAS No. 2408477-50-7

KS106( —— )

Catalog No. M35694 CAS No. 2408477-50-7

KS106 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activity, inhibits ALDH1A1, ALDH2, and ALDH3A1 with IC50 of 334, 2137, and 360 nM, respectively.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    KS106
  • Note
    Research use only, not for human use.
  • Brief Description
    KS106 is a selective and potent ALDH inhibitor with antiproliferative and anticancer activity, inhibits ALDH1A1, ALDH2, and ALDH3A1 with IC50 of 334, 2137, and 360 nM, respectively.
  • Description
    KS106 is a potent ALDH inhibitor with IC50s of 334, 2137, 360 nM for ALDH1A1, ALDH2, and ALDH3A1, respectively. KS106 shows antiproliferative and anticancer effects with low low toxic.KS106 significantly increases ROS activity, lipid peroxidation and toxic aldehyde accumulation. KS106 induces apoptosis and cell cycle arrest at the G2/M phase.
  • In Vitro
    KS106 (compound 3h) (0-100 μM; 72 h) shows anti-proliferative activity with IC50s of 5.7, 5.7, 5.7, 4.9, 1.5, 2.6, 1.6, 1.7, 2.2, 20.7 μM for UACC 903, 1205 Lu, HCT116, HT29, NCIH929, U266, RPMI8226, MM.1R, MM.1S, FF2441 cells, respectively.KS106 (5 μM, 24 h) induces apoptosis and cell cycle arrest at the G2/M phase.Apoptosis Analysis Cell Line:HCT116, HT29 cells Concentration:5 μM Incubation Time:24 h Result:Induced cell apoptosis.Cell Cycle Analysis Cell Line:HCT116 cells Concentration:5 μM Incubation Time:24 h Result:Induced cell cycle arrest at G2/M phase.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis | Dehydrogenase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2408477-50-7
  • Formula Weight
    474.3
  • Molecular Formula
    C18H15BrF3N3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (210.84 mM; Ultrasonic )
  • SMILES
    Br.NC(=N)SCc1ccc(CN2C(=O)C(=O)c3cc(ccc23)C(F)(F)F)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dinavahi SS, et al. Design, synthesis characterization and biological evaluation of novel multi-isoform ALDH inhibitors as potential anticancer agents. Eur J Med Chem. 2020 Feb 1;187:111962.?
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