Cart
sales@molnova.com
Nrf2 activator-4
CAS No. 2383016-68-8
Nrf2 activator-4( —— )
Catalog No. M35687 CAS No. 2383016-68-8
Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 105 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameNrf2 activator-4
-
NoteResearch use only, not for human use.
-
Brief DescriptionNrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.
-
DescriptionNrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorReactive Oxygen Species | Nrf2
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2383016-68-8
-
Formula Weight468.9
-
Molecular FormulaC23H24ClF3N2O3
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (213.27 mM; Ultrasonic )
-
SMILESCl.CN1CCN(CC1)C(=O)COc1ccc(cc1)C(=O)\C=C\c1ccccc1C(F)(F)F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777. ?
molnova catalog
related products
-
WUN29654
WUN29654 is a Thalidomide analog and CRBN modulator,has an IC50 of 3.5 μM and a Ki of 0.98 μM.
-
TIM-3-IN-2
TIM-3-IN-2 is a Tim3 inhibitor that inhibits the binding of TIM-3 to PtdSer, CEACAM1, and Gal-9 and inhibits the action of TIM-3.TIM-3-IN-2 is able to reverse TIM-3-mediated pro-inflammatory cytokine action.
-
12-Distearoyl-sn-gly...
12-Distearoyl-sn-glycero-3-phosphorylethanolamine is a phosphatidylethanolamine (PE or GPEtn). The stearic acid moieties are derived from animal fats coco butter and sesame oil. Phospholipids are ubiquitous in nature and are key components of the lipid bilayer of cells as well as being involved in metabolism and signaling.
