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Nrf2 activator-4
CAS No. 2383016-68-8
Nrf2 activator-4( —— )
Catalog No. M35687 CAS No. 2383016-68-8
Nrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNrf2 activator-4
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NoteResearch use only, not for human use.
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Brief DescriptionNrf2 activator-4 is an Nrf2 activator that inhibits the production of reactive oxygen species in microglia for the treatment of fatty liver disease associated with metabolic dysfunction in humans.
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DescriptionNrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 μM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorReactive Oxygen Species | Nrf2
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Research Area——
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Indication——
Chemical Information
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CAS Number2383016-68-8
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Formula Weight468.9
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Molecular FormulaC23H24ClF3N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (213.27 mM; Ultrasonic )
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SMILESCl.CN1CCN(CC1)C(=O)COc1ccc(cc1)C(=O)\C=C\c1ccccc1C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777. ?
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