PKM2 activator 2

Research use only, not for human use.

PKM2 activator 2, with an AC50 value of 66 nM, is a pyruvate kinase M2 (PKM2) activator that demonstrates anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through the activation of PKM2.

PKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells.

PKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines .PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC50 value of 66 nM in the luciferase-coupled assay.

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Others

Other Targets

PKM

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1186660-06-9

452.49

C20H18F2N2O4S2

>98% (HPLC)

In Vitro:?DMSO : 5 mg/mL (11.05 mM; Ultrasonic (<60°C)

Fc1cccc(F)c1S(=O)(=O)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1

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(-20℃)

With Ice Pack

≥ 2 years