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PKM2 activator 2
CAS No. 1186660-06-9
PKM2 activator 2( —— )
Catalog No. M35668 CAS No. 1186660-06-9
PKM2 activator 2, with an AC50 value of 66 nM, is a pyruvate kinase M2 (PKM2) activator that demonstrates anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through the activation of PKM2.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 128 | In Stock |
|
| 5MG | 117 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 353 | In Stock |
|
| 50MG | 523 | In Stock |
|
| 100MG | 786 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1562 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePKM2 activator 2
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NoteResearch use only, not for human use.
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Brief DescriptionPKM2 activator 2, with an AC50 value of 66 nM, is a pyruvate kinase M2 (PKM2) activator that demonstrates anti-tumor proliferative properties and attenuates the Warburg effect by normalizing cellular glycolytic metabolism through the activation of PKM2.
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DescriptionPKM2 activator 2 is a pyruvate kinase M2 (PKM2) activitor with an AC50 value of 66 nM. PKM2 activator 2 may show anti-tumor proliferation effect and relieve the Warburg effect, while PKM2 activation can restore normal glycolytic metabolism in cells.
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In VitroPKM2 leads to increased availability of glycolyctic intermediates for biosynthesis of amino acids, nucleic acids, and lipid building blocks for cellular construction in cancer cells. However, PKM2 shows down-regulated expression and dimeric form in tumors and cancer cell lines .PKM2 activator 2 (compound 28) is a highly potent activator, activates pyruvate kinase with an AC50 value of 66 nM in the luciferase-coupled assay.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPKM
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Research Area——
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Indication——
Chemical Information
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CAS Number1186660-06-9
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Formula Weight452.49
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Molecular FormulaC20H18F2N2O4S2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 5 mg/mL (11.05 mM; Ultrasonic (<60°C)
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SMILESFc1cccc(F)c1S(=O)(=O)N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Boxer MB, et al. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. J Med Chem. 2010 Feb 11;53(3):1048-55. ?
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