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COX-2-IN-6
CAS No. 2756347-91-6
COX-2-IN-6( —— )
Catalog No. M35615 CAS No. 2756347-91-6
COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is used to prevent colorectal cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
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| 10MG | 98 | In Stock |
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| 25MG | 179 | In Stock |
|
| 50MG | 252 | In Stock |
|
| 100MG | 372 | In Stock |
|
| 200MG | 505 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCOX-2-IN-6
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NoteResearch use only, not for human use.
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Brief DescriptionCOX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is used to prevent colorectal cancer.
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DescriptionCOX-2-IN-6 (compound 10) is an orally active, gut-restricted and selective cyclooxygenase-2 (COX-2) inhibitor for colorectal Chemoprevention of cancer. COX-2-IN-6 selectively targets COX-2 with an IC50 of 0.84 μM and a Ki of 69 nM. COX-2-IN-6 also inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.
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In Vitro——
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In VivoAnimal Model:APCmin/+ mouse model Dosage:30 mg/kg, 100 mg/kg, 300 mg/kg Administration:PO; daily in chow diet Result:Significantly decreased [18F]-FDG uptake and polyp area.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetCOX
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RecptorCOX | Prostaglandin Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2756347-91-6
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Formula Weight409.5
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Molecular FormulaC20H27NO6S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (244.20 mM; Ultrasonic )
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SMILESO(CC(C)(C)O)C1=C(C=C(CO)C(OCCC)=N1)C2=CC=C(S(C)(=O)=O)C=C2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Z, et al. Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer. J Med Chem. 2021 Aug 12;64(15):11570-11596. ?
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