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Osunprotafib

CAS No. 2489404-97-7

Osunprotafib( —— )

Catalog No. M35583 CAS No. 2489404-97-7

Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.

Purity : >98% (HPLC)

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Biological Information

Product Name

Osunprotafib
Note

Research use only, not for human use.
Brief Description

Osunprotafib (ABBV-CLS-484) is a potent, orally bioavailable PTP1B/PTPN2 inhibitor in clinical trials for solid tumors.
Description

Osunprotafib (ABBV-CLS-484) is a potent PTPN1 and PTPN2 inhibitor with subnanomolar activity. Osunprotafib has antitumor activity, enhances the immune response and increases the sensitivity of tumors to immune-mediated killing.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

Phosphatase
Recptor

Phosphatase
Research Area

——
Indication

——

Chemical Information

CAS Number

2489404-97-7
Formula Weight

385.45
Molecular Formula

C17H24FN3O4S
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 62.5 mg/mL (162.15 mM; Ultrasonic )
SMILES

CC(C)CCN[C@@H]1CCc2cc(O)c(N3CC(=O)NS3(=O)=O)c(F)c2C1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Philip R. Kym, et al. Protein tyrosine phosphatase inhibitors and methods of use thereof. WO2022056281A1.

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