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JAK-IN-21

CAS No. 2445499-20-5

JAK-IN-21( —— )

Catalog No. M35565 CAS No. 2445499-20-5

JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 511 Get Quote
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Biological Information

  • Product Name
    JAK-IN-21
  • Note
    Research use only, not for human use.
  • Brief Description
    JAK-IN-21 is a selective and potent JAK inhibitor that inhibits JAK1, JAK2, J2V617F and TYK2 with IC50 values of 1.73, 2.04, 109 and 62.9 nM, respectively.
  • Description
    JAK-IN-21 (Example 4) is a selective and potent JAK inhibitor with IC50s of 1.73, 2.04, 109 and 62.9 nM against JAK1, JAK2, J2V617F and TYK2, respectively.
  • In Vitro
    JAK-IN-21 (Example 4) doses not inhibit CYPs and shows good liver microsome stability.
  • In Vivo
    JAK-IN-21 (Example 4) shows low bioavailability (F=1.9%).Animal Model:SD rats Dosage:10 mg/kg Administration:Oral gavage (Pharmacokinetic Study).
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    JAK
  • Recptor
    JAK | Tyrosine Kinases
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2445499-20-5
  • Formula Weight
    372.38
  • Molecular Formula
    C19H16N8O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (335.68 mM; Ultrasonic )
  • SMILES
    CC=1C(=NC(NC2=CN(CC#N)N=C2)=NC1)C3=CC=C(C(NCC#N)=O)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Zhaokui WAN, et al. Benzamides of pyrazolyl-amino-pyrimidinyl derivatives, and compositions and methods thereof. Patent WO2020119819.
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