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DSS30

CAS No. 883027-32-5

DSS30( —— )

Catalog No. M35558 CAS No. 883027-32-5

DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    DSS30
  • Note
    Research use only, not for human use.
  • Brief Description
    DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).
  • Description
    DSS30 is a P25/CDK5 inhibitor that reduces β-amyloid (Aβ) secretion by inhibiting amyloid precursor protein lyase 1 (BACEl) phosphorylation. DSS30 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
  • In Vitro
    DSS30 (50 μM, 2 hours) inhibits the activity of the P25/CDK5 complex by up to 50% and the phosphorylation of BACE1 or Tau.Western Blot Analysis Cell Line:Expressed P25 PC12tet-off cell lines Concentration:50 μM Incubation Time:8 hours Result:Inhibited BACE1 phosphorylation by 12%.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    Beta Amyloid
  • Recptor
    Beta Amyloid | CDK | BACE
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    883027-32-5
  • Formula Weight
    367.87
  • Molecular Formula
    C16H14ClNO3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC=1C=2C(SC1S(NC3=C(OC)C=CC=C3)(=O)=O)=CC=C(Cl)C2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Sul-Hee Chung, et al. Pharmaceutical composition comprising a p25/cdk5 inhibitor for preventing or treating a neurodegenerative disease. WO2006075808
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