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APX2039
CAS No. 2342606-49-7
APX2039( —— )
Catalog No. M35548 CAS No. 2342606-49-7
APX2039 is an orally active fungal Gwt1 enzyme inhibitor and a prodrug of the novel Gwt2096 inhibitor APX1.APX2039 exhibits potent anti-Kryptococcal activity against C. neoformans and C. gattii.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 303 | In Stock |
|
| 5MG | 275 | In Stock |
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| 10MG | 411 | In Stock |
|
| 25MG | 725 | In Stock |
|
| 50MG | 1014 | In Stock |
|
| 100MG | 1395 | In Stock |
|
| 200MG | 1841 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAPX2039
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NoteResearch use only, not for human use.
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Brief DescriptionAPX2039 is an orally active fungal Gwt1 enzyme inhibitor and a prodrug of the novel Gwt2096 inhibitor APX1.APX2039 exhibits potent anti-Kryptococcal activity against C. neoformans and C. gattii.
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DescriptionAPX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMicrobiology/Virology
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TargetAntifungal
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RecptorAntifungal
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Research Area——
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Indication——
Chemical Information
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CAS Number2342606-49-7
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Formula Weight362.36
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Molecular FormulaC20H15FN4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (275.97 mM; Ultrasonic )
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SMILESNc1ncccc1-c1cc(Cc2ccc(Oc3cccc(F)n3)cc2)no1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Karen J Shaw, et al. 168. Efficacy of the Novel gwt1 Inhibitor APX2039 in a Rabbit Model of cryptococcus Meningitis. Open Forum Infect Dis. 2020 Dec 31.
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