NSC 694623

CAS No. 907957-34-0

NSC 694623( —— )

Catalog No. M35440 CAS No. 907957-34-0

NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 of 15.9 μM against recombinant HAT p300/CBP-associated factor (PCAF) and exhibits anti-proliferative activity against certain cancer cells, making it useful for anti-cancer research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 93 In Stock
10MG 141 In Stock
25MG 282 In Stock
50MG 516 In Stock
100MG 728 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    NSC 694623
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 of 15.9 μM against recombinant HAT p300/CBP-associated factor (PCAF) and exhibits anti-proliferative activity against certain cancer cells, making it useful for anti-cancer research.
  • Description
    NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer.
  • In Vitro
    NSC 694623 has antiproliferative activity against SK-N-SH with an IC50 of 8.93 μM, and inhibits 21% of HCT116 at 25 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Histone Acetyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    907957-34-0
  • Formula Weight
    284.38
  • Molecular Formula
    C16H16N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (439.55 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1N(SC=2C1=CC=CN2)C3=CC=C(CCCC)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.?
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