Cart
sales@molnova.com
Terodiline
CAS No. 15793-40-5
Terodiline( —— )
Catalog No. M35434 CAS No. 15793-40-5
Terodiline is a seconal amine with anticholinergic and calcium antagonistic properties that blocks the hERG current (IC50: 375 nM).Terodiline is cardiotoxic and has been used in the study of disorders caused by urethral muscle instability.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 686 | In Stock |
|
| 10MG | 938 | In Stock |
|
| 25MG | 1444 | In Stock |
|
| 50MG | 1841 | In Stock |
|
| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTerodiline
-
NoteResearch use only, not for human use.
-
Brief DescriptionTerodiline is a seconal amine with anticholinergic and calcium antagonistic properties that blocks the hERG current (IC50: 375 nM).Terodiline is cardiotoxic and has been used in the study of disorders caused by urethral muscle instability.
-
DescriptionTerodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence.
-
In Vitro——
-
In VivoTerodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg).Animal Model:Fmale or male Hartley guinea pigs (200-600 g)Dosage:80 mg/kg Administration:Administered S.C. Result:Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
-
Synonyms——
-
PathwayCell Cycle/DNA Damage
-
TargetAChR
-
RecptorAChR | HER | Calcium Channel
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number15793-40-5
-
Formula Weight281.44
-
Molecular FormulaC20H27N
-
Purity>98% (HPLC)
-
Solubility——
-
SMILESC=1C=CC(=CC1)C(C=2C=CC=CC2)CC(NC(C)(C)C)C
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Ruth L Martin, et al. In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience. J Cardiovasc Pharmacol.?2006 Nov;48(5):199-206.?
molnova catalog
related products
-
Ethyl (triphenylphos...
Ethyl (triphenylphosphoranylidene) acetate may act as an cholinesterase inhibitor that inhibits AChE and BChE.
-
(S)-(+)-Dimethindene...
(S)-(+)-Dimethindene maleate is an orally available, selective muscarinic M2 receptor and histamine H1 receptor antagonist that also inhibits muscarinic M1, M3, and M4 receptors.
-
Desformylflustrabrom...
Desformylflustrabromine hydrochloride (dFBr hydrochloride) is a selective agonist of nicotinic acetylcholine receptor (nAChR) in α4β2 neurons, with pEC50 of 6.48.
