AP-C5

Research use only, not for human use.

AP-C5 is a compound with selective inhibition of guanosine 3',5' cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII), with a Pic50 value of 7.2 for cGMP, and can be used in the study of diarrheal diseases.

AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease. AP-C5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue.AP-C5 potentiates cAMP signaling by PDE inhibition.AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.

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Microbiology/Virology

Parasite

Parasite

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2234272-10-5

275.31

C16H13N5

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (90.81 mM; Ultrasonic (<60°C)

N(CC#C)C=1N=C(C2=CC=C(C=C2)N3C=CN=C3)C=CN1

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(-20℃)

With Ice Pack

≥ 2 years