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NLRP3/AIM2-IN-3
CAS No. 1787787-60-3
NLRP3/AIM2-IN-3( —— )
Catalog No. M35421 CAS No. 1787787-60-3
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 71 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 104 | In Stock |
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| 25MG | 217 | In Stock |
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| 50MG | 346 | In Stock |
|
| 100MG | 555 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1172 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNLRP3/AIM2-IN-3
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NoteResearch use only, not for human use.
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Brief DescriptionNLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M.
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DescriptionNLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNF-κB
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TargetNOD
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RecptorNOD | AIM2
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Research Area——
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Indication——
Chemical Information
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CAS Number1787787-60-3
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Formula Weight266.29
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Molecular FormulaC16H14N2O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (938.83 mM; Ultrasonic )Methanol : 50 mg/mL (187.77 mM; Ultrasonic)
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SMILESOc1cccc(NC(=O)Cc2ccc3cc[nH]c3c2)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jiao Y, et al. Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. Eur J Med Chem. 2022 Feb 11;232:114194.?
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