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MT189
CAS No. 1885900-35-5
MT189( —— )
Catalog No. M35337 CAS No. 1885900-35-5
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 29 | In Stock |
|
| 5MG | 50 | In Stock |
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| 10MG | 78 | In Stock |
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| 25MG | 158 | In Stock |
|
| 50MG | 221 | In Stock |
|
| 100MG | 326 | In Stock |
|
| 200MG | 445 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMT189
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NoteResearch use only, not for human use.
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Brief DescriptionMT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity.
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DescriptionAntiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.
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In VitroAntiproliferative agent-14 (compound 3b) shows antiproliferative activity against HeLa cell (IC50=13 nM).Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMicrotubule Associated
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Research Area——
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Indication——
Chemical Information
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CAS Number1885900-35-5
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Formula Weight363.38
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Molecular FormulaC21H18FN3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 100 mg/mL (275.19 mM)
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SMILESCOc1ccc(CNc2c(nc3ccc(F)cn23)-c2ccccc2O)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372. ?
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