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MT189

CAS No. 1885900-35-5

MT189( —— )

Catalog No. M35337 CAS No. 1885900-35-5

MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MT189
  • Note
    Research use only, not for human use.
  • Brief Description
    MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity.
  • Description
    Antiproliferative agent-14 (compound 3b) a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the ability to arrest cells at G2/M phases of the cell cycle.
  • In Vitro
    Antiproliferative agent-14 (compound 3b) shows antiproliferative activity against HeLa cell (IC50=13 nM).Antiproliferative agent-14 shows inhibition of colchicine binding activity, with 72.2% inhibitory percentage.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Microtubule Associated
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1885900-35-5
  • Formula Weight
    363.38
  • Molecular Formula
    C21H18FN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (275.19 mM)
  • SMILES
    COc1ccc(CNc2c(nc3ccc(F)cn23)-c2ccccc2O)cc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. An W, et al. Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. Eur J Med Chem. 2016 Apr 13;112:367-372. ?
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