Home - Products - GPCR/G Protein - PAR - AY 77

AY 77

CAS No. 1835734-92-3

AY 77( —— )

Catalog No. M35259 CAS No. 1835734-92-3

AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
5MG	844	In Stock
10MG	1131	In Stock
25MG	1682	In Stock
50MG	2223	In Stock
100MG	3004	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

AY 77
Note

Research use only, not for human use.
Brief Description

AY 77 (Unk-Cha-Chg-NH2) is a potent and selective PAR2 agonist. AY 77 showed selectivity for Ca2+ and ERK1/2 signaling (ec50 value of Ca2+ release was 40 nM and ec50 value of ERK1/2 phosphorylation was 2 μM).
Description

AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

GPCR/G Protein
Target

PAR
Recptor

Protease-activated Receptor | Calcium Channel | ERK
Research Area

——
Indication

——

Chemical Information

CAS Number

1835734-92-3
Formula Weight

404.5
Molecular Formula

C21H32N4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

[C@H](CC1CCCCC1)(C(N[C@H](C(N)=O)[C@@H]2CCCCC2)=O)NC(=O)C3=CC=NO3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kl?sel I, et al. Discovery of Novel Nonpeptidic PAR2 Ligands. ACS Med Chem Lett. 2020 May 22;11(6):1316-1323.?

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

related products

SSR128129E

SSR128129E is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.
FSLLRY-NH2

Selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch.
IUN76750

IUN76750 is a PAR-?2 signaling pathway inhibitor?with anti-inflammatory and anticancer effects.

Sign In Join Free