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EM 163
CAS No. 1206480-93-4
EM 163( —— )
Catalog No. M35255 CAS No. 1206480-93-4
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 437 | In Stock |
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| 5MG | 278 | In Stock |
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| 10MG | 373 | In Stock |
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| 25MG | 625 | In Stock |
|
| 50MG | 871 | In Stock |
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| 100MG | 1181 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2372 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEM 163
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NoteResearch use only, not for human use.
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Brief DescriptionEM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein.
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DescriptionEM-163 is a summative BB-Loop analog. EM-163 can alleviate inflammation and prevent death from toxic shock by targeting the TIR domain of MyD88. EM-163 can be used in the study of SEB poisoning (SEB: Staphylococcal enterotoxin B).
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In Vitro——
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In VivoAnimal Model:SEB-induced BALB/c mice model Dosage:0.21 mg/mouse, 0.42 mg/mouse, 0.86 mg/mouse Administration:Intraperitoneal injection (i.p.); Single dose. Before SEB treatment (0.5 μg/mouse, 5 μg/mouse; i.p.; single dose) and LPS treatment.Result:Delayed mouse death at a dose of 0.21 mg/mouse, and protected mice from death at either dose of 0.42 mg/mouse or 0.86 mg/mouse.Delayed mouse death even at high doses of SEB (5 μg).
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Synonyms——
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PathwayImmunology/Inflammation
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TargetMyD88
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RecptorMyD88 | p38 MAPK | IL Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1206480-93-4
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Formula Weight849.88
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Molecular FormulaC44H60IN5O4
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Purity>98% (HPLC)
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Solubility——
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SMILESN([C@H](C(=O)N1CCCC1)C(C)C)(C(=O)C2=C[N+](C)=C(C(N([C@H](C(=O)N3CCCC3)C(C)C)CCCC4=CC=CC=C4)=O)C=C2)CCCC5=CC=CC=C5.[I-]
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Kissner TL, et al. Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88. PLoS One. 2012;7(7):e40773.?
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