Cart
sales@molnova.com
PA-8
CAS No. 878437-15-1
PA-8( —— )
Catalog No. M35242 CAS No. 878437-15-1
PA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
|
| 5MG | 37 | In Stock |
|
| 10MG | 68 | In Stock |
|
| 25MG | 147 | In Stock |
|
| 50MG | 253 | In Stock |
|
| 100MG | 445 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePA-8
-
NoteResearch use only, not for human use.
-
Brief DescriptionPA-8 is a small molecule receptor antagonist for PACAP Type I (PAC1) that is selective, effective, and orally active. PA-8 inhibits PacAP-induced CREB phosphorylation at PAC1- receptors, but does not inhibit VPAC1- or vpac2 receptors.
-
DescriptionPA-8 is a potent, selective and orally active PACAP type I (PAC1) receptor antagonist. PA-8 inhibits the phosphorylation of CREB induced by PACAP in PAC1-, but not VPAC1- or VPAC2-receptor. PA-8 also inhibits PACAP-induced cAMP elevation with an IC50 of 2 nM.
-
In Vitro——
-
In VivoAnimal Model:Male ddY mice (6 weeks old) injected with PACAP (100 pmol) Dosage:100 pmol/5 μL Administration:Intrathecal injection; once Result:Inhibited PACAP-induced aversive responses and mechanical allodynia in vivo.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorPACAP
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number878437-15-1
-
Formula Weight342.35
-
Molecular FormulaC17H18N4O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 25 mg/mL (73.02 mM; Ultrasonic (<60°C)
-
SMILESCOc1cc(ccc1OCC=C)C1CC(=O)Nc2nc(N)[nH]c(=O)c12
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
-
Dieugenol
Dieugenol is a neolignan that has been found in N. leucantha and has antioxidative and antiprotozoal activities. It inhibits the formation of thiobarbituric acid reactive substances (TBARS) and scavenges superoxide anions, but not hydroxyl radicals, in cell-free assays. It has anti-trypanosomal activity against T. cruzi amastigotes and trypomastigotes (IC50s=15.1 and 11.5 μM, respectively) but is cytotoxic to NCTC L-929 fibroblasts with a 50% cytotoxic concentration (CC50) value of 58.2 μM.2 Dieugenol (15 μM) disrupts the integrity of the T. cruzi trypomastigote plasma membrane but does not induce the production of reactive oxygen species (ROS) in trypomastigotes or LPS-stimulated and unstimulated isolated mouse peritoneal macrophages.
-
Madecassic acid
Madecassic acid is extracted from the whole herb of Centella asiatica.
-
Echinatin
Echinatin disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria.
