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SW157765
CAS No. 332063-87-3
SW157765( —— )
Catalog No. M35205 CAS No. 332063-87-3
SW157765 is a selective glucose transporter GLUT8 (SLC2A8) inhibitor, a prodrug of many compounds, that selectively inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitive cells in a dose-dependent manner, and can be used for the study of lung cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameSW157765
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NoteResearch use only, not for human use.
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Brief DescriptionSW157765 is a selective glucose transporter GLUT8 (SLC2A8) inhibitor, a prodrug of many compounds, that selectively inhibits the uptake of fluorescent 2-deoxyglucose (2DG) in SW157765-sensitive cells in a dose-dependent manner, and can be used for the study of lung cancer.
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DescriptionSW157765 is a selective non-canonical glucose transporter GLUT8 (SLC2A8) inhibitor. KRAS/KEAP1 double mutant NSCLC cells are selectively sensitive to the SW157765, due to the convergent consequences of dual KRAS and NRF2 modulation of metabolic and xenobiotic gene regulatory programs.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptortransporter
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Research Area——
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Indication——
Chemical Information
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CAS Number332063-87-3
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Formula Weight331.32
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Molecular FormulaC19H13N3O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (75.46 mM; Ultrasonic (<60°C)
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SMILESO=C(Nc1ccc2oc(nc2c1)-c1ccncc1)\C=C\c1ccco1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Pine SR, et al. Identifying therapeutic vulnerabilities in lung cancer: application of a chemistry-first approach. Transl Lung Cancer Res. 2018;7(Suppl 3):S265-S269.?
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