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UZH2

CAS No. 2756566-45-5

UZH2( —— )

Catalog No. M35203 CAS No. 2756566-45-5

UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    UZH2
  • Note
    Research use only, not for human use.
  • Brief Description
    UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.
  • Description
    UZH2 is a potent and selective METTL3 inhibitor with an IC50 value of 5 nM.
  • In Vitro
    Western Blot Analysis Cell Line:MOLM-13 cells Concentration:0-25 μM Incubation Time:1h Result:Stabilized METTL3 in a dosedependent manner at 54 °C.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2756566-45-5
  • Formula Weight
    513.63
  • Molecular Formula
    C27H37F2N7O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (97.35 mM; Ultrasonic )
  • SMILES
    CNc1cc(ncn1)N1CCC2(CC1)CN(CC(=O)N2)c1cc(F)c(CN2CCC(C)(C)CC2)cc1F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dolbois A, et al. 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J Med Chem. 2021 Sep 9;64(17):12738-12760. ?
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