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Acoramidis hydrochloride
CAS No. 2242751-53-5
Acoramidis hydrochloride( —— )
Catalog No. M35149 CAS No. 2242751-53-5
Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 88 | Get Quote |
|
| 5MG | 141 | Get Quote |
|
| 10MG | 226 | Get Quote |
|
| 25MG | 365 | Get Quote |
|
| 50MG | 522 | Get Quote |
|
| 100MG | 691 | Get Quote |
|
| 500MG | 1386 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameAcoramidis hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionAcoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis.
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DescriptionAcoramidis (AG10) hydrochloride is an orally active and selective kinetic stabilizer of WT and V122I-TTR (transthyretin). Acoramidis (AG10) hydrochloride is used in the study for transthyretin amyloidosis.
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In VitroWestern Blot Analysis.Cell Line:Human serum (TTR ～5 μM).Concentration:0.1 and 10 μM.Incubation Time:72 h.Result:Was significantly more effective than tafamidis in stabilizing TTR.The concentration of AG10 to 10 μM resulted in stabilization of almost all of TTR in serum.
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In VivoAnimal Model:Wistar rats.Dosage:50 mg/kg/d (Toxicity Analysis).Administration:Oral gavage, daily for 28 d.Result:Showed the plasma Cmax of ～40 μM and histopathological evaluation of liver, kidney, heart, spleen, thymus, and lung showed no signs of pathologic processes in the AG10-treated animals
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number2242751-53-5
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Formula Weight328.77
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Molecular FormulaC15H18ClFN2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (190.10 mM; Ultrasonic ) H2O : < 0.1 mg/mL (insoluble)
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SMILESCl.Cc1n[nH]c(C)c1CCCOc1cc(ccc1F)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Sravan C Penchala, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9992-7.?
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