Ethaselen( —— )

Catalog No. M35139 CAS No. 217798-39-5

Ethaselen (BBSKE) is an orally active and selective thioredoxin reductase 1 (TrxR) inhibitor with anticancer activity that directly inhibits TrxR1 activity and is commonly used in combination with oxaliplatin to inhibit tumor growth.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	258	In Stock
5MG	235	In Stock
10MG	376	In Stock
25MG	731	In Stock
50MG	1004	In Stock
100MG	1349	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

Ethaselen
Note

Research use only, not for human use.
Brief Description

Ethaselen (BBSKE) is an orally active and selective thioredoxin reductase 1 (TrxR) inhibitor with anticancer activity that directly inhibits TrxR1 activity and is commonly used in combination with oxaliplatin to inhibit tumor growth.
Description

Ethaselen (BBSKE) is an orally active, selective thioredoxin reductase (TrxR) inhibitor with IC50s of 0.5 and 0.35 μM for the wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique selenocysteine-cysteine redox pair in the C-terminal active site of mammalian TrxR1. Ethaselen, an organoselenium compound, is a potent antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR.
In Vitro

Cell Viability Assay Cell Line:A549 cell Concentration:2.5, 5, 7.5, 10 μM Incubation Time:12, 24 hours Result:Suppressed A549 cell viability in a both concentration- and time-dependent manner.
In Vivo

Animal Model:Five-week-old female BALB/c nude mice with A549 cell Dosage:36, 72, 108 mg/kg Administration:PO; daily; for 10 days Result:Showed increased inhibition of tumor growth, and the inhibition levels increased with the dose. The TrxR activity levels of the high dose group (108 mg/kg) decreased more than the middle dose group (72 mg/kg) and low dose group (36 mg/kg).
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

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Chemical Information

CAS Number

217798-39-5
Formula Weight

422.2
Molecular Formula

C16H12N2O2Se2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 12.5 mg/mL (29.61 mM; Ultrasonic (<60°C)
SMILES

O=C1C=2C=CC=CC2[Se]N1CCN3[Se]C=4C=CC=CC4C3=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Lihui Wang, et al. Ethaselen: a potent mammalian thioredoxin reductase 1 inhibitor and novel organoselenium anticancer agent. Free Radic Biol Med. 2012 Mar 1;52(5):898-908.?

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