FSCPX

Research use only, not for human use.

FSCPX is a potent and selective irreversible antagonist of the A1 adenosine receptor (A1AR), exhibiting low nanomolar binding potency.

FSCPX is a potent and selective irreversible antagonist of A1 adenosine receptor (A1AR), with low nanomolar potency for binding to the A1AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium.

FSCPX irreversibly blocks the binding of [3H]-8-cyclopentyl-1,3dipropylxanthine ([3H]DPCPX), with an IC50 of 11.8±3.2 nM in DDT1 MF2 cells.FSCPX (20 μM; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells.FSCPX (2-20 μM; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70.

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GPCR/G Protein

Adenosine Receptor

Adenosine Receptor

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156547-56-7

506.55

C23H27FN4O6S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (98.71 mM; Ultrasonic (<60°C)

CCCn1c(=O)n(CCCOC(=O)c2ccc(cc2)S(F)(=O)=O)c2[nH]c(nc2c1=O)C1CCCC1

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(-20℃)

With Ice Pack

≥ 2 years