MnTBAP chloride( —— )

Catalog No. M35013 CAS No. 55266-18-7

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MnTBAP chloride
Note

Research use only, not for human use.
Brief Description

MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2.
Description

MnTBAP chloride is a superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. MnTBAP chloride is a manganic porphyrin complex and has anti-oxidative property. MnTBAP chloride mediates anti-inflammatory effects through upregulation of BMPR-II and inhibition of the NFκB signaling. MnTBAP chloride has the potential for the fibrotic response in chronic kidney diseases (CKDs) research.
In Vitro

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In Vivo

Animal Model:C57BL/6J mice with 5/6 nephrectomy (Nx)Dosage:10?mg/kg Administration:IP; three times per week for twelve weeks Result:Attenuated renal fibrosis in 5/6 Nx mice and reduced protein expressions of fibronectin, collagen III in remnant kidneys.
Synonyms

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Pathway

Others
Target

Antioxidant
Recptor

Antioxidant | NF-κB
Research Area

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Indication

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CAS Number

55266-18-7
Formula Weight

876.13
Molecular Formula

C48H25ClMnN4O8
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (113.75 mM; Ultrasonic )0.5 M NaOH : 20 mg/mL (22.75 mM; Ultrasonic)1M NaOH : 10 mg/mL (11.37 mM; ultrasonic and adjust pH to 8 with NaOH)
SMILES

[H+].O=C([O-])C=1C=CC(=CC1)C2=C3C=CC=4C(C=5C=CC(=CC5)C(=O)[O-])=C6C=CC7=C(C8=CC=C(C=C8)C(=O)[O-])C=9C=CC%10=C(C%11=CC=C(C=C%11)C(=O)[O-])C%12=CC=C2[N-]%12[Mn+3]([Cl-])([N]34)([N]%109)[N-]67
Chemical Name

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1. Jing Yu, et al. MnTBAP Therapy Attenuates Renal Fibrosis in Mice With 5/6 Nephrectomy. Oxid Med Cell Longev. 2016;2016:7496930.?

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