Glucocorticoid receptor agonist-1( —— )

Catalog No. M34988 CAS No. 2166375-82-0

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Product Name

Glucocorticoid receptor agonist-1
Note

Research use only, not for human use.
Brief Description

Glucocorticoid receptor agonist-1, a potent glucocorticoid receptor agonist, has an IC50 of 2.8 nM.
Description

Glucocorticoid receptor agonist-1 is a potent glucocorticoid receptor agonist with an IC50 of 2.8 nM extracted from patent WO2017210471A1, compound 41.
In Vitro

Glucocorticoid receptor agonist immunoconjugates are useful for treating autoimmune diseases such as, but not limited to, rheumatoid arthritis, juvenile idiopathic arthritis, psoriatic arthritis, ankylosing spondylitis, adult Crohn's disease, pediatric Crohn's disease, ulcerative colitis, plaque psoriasis, hidradenitis suppurativa, uveitis, Behcets disease, a spondyloarthropathy, or psoriasis.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Glucocorticoid Receptor | ADC Cytotoxin
Research Area

——
Indication

——

CAS Number

2166375-82-0
Formula Weight

569.69
Molecular Formula

C35H39NO6
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (175.53 mM; Ultrasonic )
SMILES

[H][C@]1(O[C@]2([H])C[C@@]3([H])[C@]4([H])CCC5=CC(=O)C=C[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO)c1ccc(Cc2cccc(N)c2)cc1
Chemical Name

——

1. Michael J. Mcpherson, et al. Glucocorticoid receptor agonist and immunoconjugates thereof. WO2017210471A1.

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