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MS 15203
CAS No. 73912-52-4
MS 15203( —— )
Catalog No. M34916 CAS No. 73912-52-4
MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 65 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 57 | In Stock |
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| 10MG | 101 | In Stock |
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| 25MG | 211 | In Stock |
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| 50MG | 305 | In Stock |
|
| 100MG | 458 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 995 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMS 15203
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NoteResearch use only, not for human use.
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Brief DescriptionMS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.
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DescriptionMS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.
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In VitroMS15203 (MS0015203) dose-dependently increases [[35]S]GTPγS binding and inhibits adenylyl cyclase activity in rat hypothalamic membranes.
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In VivoMS15203 (MS0015203) (3 mg/kg; i.p.) causes an increase in neuronal activity within cells containing GPR171 in the PVN..MS15203 (3 mg/kg; i.p.) significantly increases food intake at 4 and 8 hours.MS15203 (3 mg/kg; i.p.) significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetGPR
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RecptorGPR
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Research Area——
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Indication——
Chemical Information
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CAS Number73912-52-4
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Formula Weight249.22
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Molecular FormulaC12H11NO5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (200.63 mM; Ultrasonic (<60°C)
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SMILESO=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Wardman JH, et al. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 May 31;9(430):ra55. ?
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