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MS 15203

CAS No. 73912-52-4

MS 15203( —— )

Catalog No. M34916 CAS No. 73912-52-4

MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 65 In Stock
2MG 36 In Stock
5MG 57 In Stock
10MG 101 In Stock
25MG 211 In Stock
50MG 305 In Stock
100MG 458 In Stock
200MG Get Quote In Stock
500MG 995 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    MS 15203
  • Note
    Research use only, not for human use.
  • Brief Description
    MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.
  • Description
    MS15203 is a potent and selective GPR171 agonist. MS15203 increases food intake and body weight. MS15203 increases neuronal activity. MS15203 significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.
  • In Vitro
    MS15203 (MS0015203) dose-dependently increases [[35]S]GTPγS binding and inhibits adenylyl cyclase activity in rat hypothalamic membranes.
  • In Vivo
    MS15203 (MS0015203) (3 mg/kg; i.p.) causes an increase in neuronal activity within cells containing GPR171 in the PVN..MS15203 (3 mg/kg; i.p.) significantly increases food intake at 4 and 8 hours.MS15203 (3 mg/kg; i.p.) significantly increases the abundance of the mRNAs encoding proSAAS, NPY, AgRP.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    73912-52-4
  • Formula Weight
    249.22
  • Molecular Formula
    C12H11NO5
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (200.63 mM; Ultrasonic (<60°C)
  • SMILES
    O=C(O)C1=CC(=CC(=C1)C(=O)O)NC(=O)C(=C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Wardman JH, et al. Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake. Sci Signal. 2016 May 31;9(430):ra55. ?
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