(S)-UFR2709 hydrochloride

Research use only, not for human use.

(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist with higher affinity for α4β2 nAChRs than for α7 nAChRs.

(S)-UFR2709 (hydrochloride) is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S)-UFR2709 (hydrochloride) decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S)-UFR2709 (hydrochloride) acts as an anxiolytic agent and can be used for the study of nicotine addiction.

Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, which is a molecular target for the treatment of alcohol abuse and dependence.

(S)-UFR2709 (hydrochloride) (50-100 μg/ml; 3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test, and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s, respectively at 50 and 100 μg/ml.(S)-UFR2709 (hydrochloride) (50-100 μg/ml) decreases nicotine-evoked mRNA expression of α4 nACh receptor subunit, but UFR2709 has less effect on α4 nACh receptor subunit in the brain of adult zebrafish.(S)-UFR2709 (hydrochloride) (intraperitoneal?injection; 1-10 mg/kg; daily; 17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 is 2.5 mg/kg, it induces a 56% reduction in alcohol consumption.?(S)-UFR2709 (hydrochloride) does not affect the weight or locomotor activity of the rats.Animal Model:High-alcohol-drinking UChB rats Dosage:10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg Administration: Intraperitoneal?injection; 1-10 mg/kg; daily; 17 days Result:Did not affect the weight or locomotor activity and reduced ethanol consumption and preference.

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Cell Cycle/DNA Damage

AChR

AChR

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2934318-93-9

255.74

C13H18ClNO2

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (391.02 mM; Ultrasonic) DMSO : 50 mg/mL (195.51 mM; Ultrasonic )

C(OC(=O)C1=CC=CC=C1)[C@H]2N(C)CCC2.Cl

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(-20℃)

With Ice Pack

≥ 2 years