9-hydroxy Stearic Acid

Research use only, not for human use.

9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas.

9-Hydroxyoctadecanoic acid (9-HSA) is an HDAC1 inhibitor that inhibits ～66.4% HDAC1 enzymatic activity at 5 μM. 9-Hydroxyoctadecanoic acid shows anticancer activity.

Cell Line:HT29 cell Concentration:100 μM Incubation Time:24 h Result:Decreased S-phase activity by 50.2% compared with untreated controls, and the growth inhibition was associated with a strong arrest in G0/G1.Cell Line:HT29 cell Concentration:100 μM Incubation Time:24 h Result:Increased the expression of p21WAF1。Cell Line:HT29 cell Concentration:100 μM Incubation Time:24 h Result:Induced p21WAF1 tanscript.

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Cell Cycle/DNA Damage

HDAC

HDAC

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3384-24-5

300.48

C18H36O3

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (332.80 mM)

C(C(CCCCCCCCC)O)CCCCCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years