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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - H-Leu-Leu-OMe HBr

H-Leu-Leu-OMe HBr

CAS No. 16689-14-8

H-Leu-Leu-OMe HBr( —— )

Catalog No. M34891 CAS No. 16689-14-8

H-Leu-Leu-OMe HBr (L-Leucyl-L-Leucine methyl ester HBr) is a dipeptide condensation product of L-Leucine methyl ester, a peptide that is toxic to natural killer T-cells and possesses immunosuppressive activity that abrogates all natural killer (NK) cell functions in mixed lymphocyte populations.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    H-Leu-Leu-OMe HBr
  • Note
    Research use only, not for human use.
  • Brief Description
    H-Leu-Leu-OMe HBr (L-Leucyl-L-Leucine methyl ester HBr) is a dipeptide condensation product of L-Leucine methyl ester, a peptide that is toxic to natural killer T-cells and possesses immunosuppressive activity that abrogates all natural killer (NK) cell functions in mixed lymphocyte populations.
  • Description
    L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    16689-14-8
  • Formula Weight
    339.27
  • Molecular Formula
    C13H27BrN2O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (368.44 mM; Ultrasonic )H2O : 100 mg/mL (294.75 mM; Ultrasonic)
  • SMILES
    Br.COC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Thiele DL, et, al. The immunosuppressive activity of L-leucyl-L-leucine methyl ester: selective ablation of cytotoxic lymphocytes and monocytes. J Immunol. 1986 Feb 1;136(3):1038-48.?
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