Evixapodlin( —— )

Catalog No. M34846 CAS No. 2374856-75-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Evixapodlin
Note

Research use only, not for human use.
Brief Description

Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.
Description

Evixapodlin (GS-4224) is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. Evixapodlin has anticancer and antiviral functions.
In Vitro

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In Vivo

Animal Model:Female C57BL/6 mice injected with MC38 tumor cells Dosage:10 mg/kg, 25 mg/kg, and 50 mg/kg Administration:Intraperitoneal injection, daily, for 6 days Result:Showed greater than 90% TO on the tumors and inhibited tumor growth in vivo.
Synonyms

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Pathway

Immunology/Inflammation
Target

PD-1/PD-L1
Recptor

PD-1/PD-L1 | Antiviral | HBV
Research Area

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Indication

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CAS Number

2374856-75-2
Formula Weight

691.61
Molecular Formula

C34H36Cl2N8O4
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (72.30 mM; Ultrasonic )
SMILES

COc1nc(cnc1CNC[C@@H]1CCC(=O)N1)-c1cccc(c1Cl)-c1cccc(c1Cl)-c1cnc(CNC[C@@H]2CCC(=O)N2)c(OC)n1
Chemical Name

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1. Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1.

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