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Evixapodlin
CAS No. 2374856-75-2
Evixapodlin( —— )
Catalog No. M34846 CAS No. 2374856-75-2
Evixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 406 | In Stock |
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| 5MG | 264 | In Stock |
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| 10MG | 424 | In Stock |
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| 25MG | 748 | In Stock |
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| 50MG | 986 | In Stock |
|
| 100MG | 1330 | In Stock |
|
| 200MG | 1795 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEvixapodlin
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NoteResearch use only, not for human use.
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Brief DescriptionEvixapodlin (PD-1/PD-L1-IN 7) is a human PD-1/PD-L1 protein/protein interaction inhibitor (IC50: 0.213).Evixapodlin has anticancer and antiviral activities.
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DescriptionEvixapodlin (GS-4224) is a human PD-1/PD-L1 protein/protein interaction inhibitor with an IC50 of 0.213 nM. Evixapodlin has anticancer and antiviral functions.
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In Vitro——
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In VivoAnimal Model:Female C57BL/6 mice injected with MC38 tumor cells Dosage:10 mg/kg, 25 mg/kg, and 50 mg/kg Administration:Intraperitoneal injection, daily, for 6 days Result:Showed greater than 90% TO on the tumors and inhibited tumor growth in vivo.
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Synonyms——
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PathwayImmunology/Inflammation
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TargetPD-1/PD-L1
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RecptorPD-1/PD-L1 | Antiviral | HBV
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Research Area——
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Indication——
Chemical Information
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CAS Number2374856-75-2
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Formula Weight691.61
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Molecular FormulaC34H36Cl2N8O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (72.30 mM; Ultrasonic )
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SMILESCOc1nc(cnc1CNC[C@@H]1CCC(=O)N1)-c1cccc(c1Cl)-c1cccc(c1Cl)-c1cnc(CNC[C@@H]2CCC(=O)N2)c(OC)n1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Evangelos Aktoudianakis, et al. Pd-1/pd-l1 inhibitors. WO2019160882A1.
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