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A2ti-1
CAS No. 570390-00-0
A2ti-1( —— )
Catalog No. M34840 CAS No. 570390-00-0
A2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 302 | In Stock |
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| 5MG | 211 | In Stock |
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| 10MG | 330 | In Stock |
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| 25MG | 655 | In Stock |
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| 50MG | 1014 | In Stock |
|
| 100MG | 1386 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 2771 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameA2ti-1
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NoteResearch use only, not for human use.
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Brief DescriptionA2ti-1 is a highly selective inhibitor of annexin A2/S100A10 heterotetramer (A2t) (IC50: 24 μM) that inhibits ARV-mediated activation of Src and p38 mitogen-activated protein kinase (MAPK).
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DescriptionA2ti-1 is a selective and high-affinity annexin A2/S100A10 heterotetramer (A2t) inhibitor with an IC50 of 24 μM. A2ti-1 specifically disrupts the protein-protein interaction (PPI) between A2 and S100A10. A2ti-1 prevents human papillomavirus type 16 (HPV16) infection.
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In VitroCell Viability Assay Cell Line:HeLa cells Concentration:100 μM Incubation Time:For 72 hours Result:Reduced HPV16 PsV infection of HeLa cells in a dose-dependent manner with 100% inhibition of infection observed at 100 μM and similar results were observed in HaCaT cells.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorVirus Protease
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Research Area——
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Indication——
Chemical Information
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CAS Number570390-00-0
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Formula Weight382.48
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Molecular FormulaC20H22N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (653.63 mM; Ultrasonic )
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SMILESCCc1ccccc1-n1c(COc2ccccc2C)nnc1SCC(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Tummala R K Reddy, et al.Three-dimensional Pharmacophore Design and Biochemical Screening Identifies Substituted 1,2,4-triazoles as Inhibitors of the Annexin A2-S100A10 Protein Interaction. ChemMedChem. 2012 Aug;7(8):1435-46.?
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