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CAY10746
CAS No. 2247240-76-0
CAY10746( —— )
Catalog No. M34824 CAS No. 2247240-76-0
CAY10746 is a selective Rho kinase (ROCK) inhibitor, targeting ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 49 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 49 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 181 | In Stock |
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| 50MG | 269 | In Stock |
|
| 100MG | 425 | In Stock |
|
| 200MG | 570 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCAY10746
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NoteResearch use only, not for human use.
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Brief DescriptionCAY10746 is a selective Rho kinase (ROCK) inhibitor, targeting ROCK I and ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively.
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DescriptionCAY10746 is a selective Rho kinase (ROCK) inhibitor. CAY10746 has inhibitory activity for ROCK I, ROCK II with IC50 values of 0.014 μM and 0.003 μM, respectively. CAY10746 can be used for the research of diabetic retinopathy (DR).
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In VitroWestern Blot Analysis Cell Line:SH-SY5Y cells Concentration:0.1, 1 and 10 μM; 10 μM Incubation Time:2 h; 0.25, 1, 2 and 4 h Result:Inhibited the phosphorylation of MYPT1 but did not impact the MYPT1 expression in dose-dependence and time- dependence.Cell Proliferation Assay Cell Line:SH-SY5Y cells Concentration:1 μM Incubation Time:5 days Result:Significantly protected the cells from death. Cell Migration Assay Cell Line: HUVEC cells Concentration:1 μM Incubation Time:24 h, 36 h Result:Significantly reduced migrating cell numbers and significantly reduce the rate of wound healing at 24 h and 36 h.Apoptosis Analysis Cell Line:ex vivo DR model Concentration:1 μM Incubation Time:5 days Result: Significantly protected neuronal cells from death.
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In Vivo——
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Synonyms——
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PathwayCell Cycle/DNA Damage
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TargetROCK
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RecptorROCK
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Research Area——
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Indication——
Chemical Information
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CAS Number2247240-76-0
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Formula Weight457.48
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Molecular FormulaC26H23N3O5
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 83.33 mg/mL (182.15 mM; Ultrasonic (<60°C)
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SMILESCN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lanying Zhao, et al. Discovery of 4 H-Chromen-4-one Derivatives as a New Class of Selective Rho Kinase (ROCK) Inhibitors, which Showed Potent Activity in ex Vivo Diabetic Retinopathy Models. J Med Chem. 2019 Dec 12;62(23):10691-10710.?
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