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Lysophosphatidylcholines

CAS No. 9008-30-4

Lysophosphatidylcholines( —— )

Catalog No. M34810 CAS No. 9008-30-4

Lysophosphatidylcholines (Lyso-Lecithins (egg)) are orally active lipids that induce cell damage and apoptosis, and induce demyelination.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Lysophosphatidylcholines
  • Note
    Research use only, not for human use.
  • Brief Description
    Lysophosphatidylcholines (Lyso-Lecithins (egg)) are orally active lipids that induce cell damage and apoptosis, and induce demyelination.
  • Description
    Lysophosphatidylcholines is an orally active lysolipid and a component of oxidized low density lipoprotein (LDL). Lysophosphatidylcholines induces cell injury, the production of IL-1β and apoptosis. Lysophosphatidylcholines has a proactive effect on sepsis.
  • In Vitro
    Cell Cytotoxicity Assay Cell Line:HUVEC Concentration:3 μM, 10μM, 30 μM, 100 μM Incubation Time:24 h Result:Reduced HUVEC viability in a concentration-dependent manner.Western Blot Analysis Cell Line:HUVEC Concentration:75 μM Incubation Time:24 h Result:Showed both ERK1/2 and p38-MAPK phosphorylation.
  • In Vivo
    Animal Model:Albino ICR mice Dosage:0.1 mg/kg, 1 mg/kg, 10 mg/kg, 20 mg/kg Administration:Oral Result:Provided significant protection against cecal ligation and puncture (CLP)-induced lethality at a dose of 1 mg/kg.
  • Synonyms
    ——
  • Pathway
    Apoptosis
  • Target
    Apoptosis
  • Recptor
    Apoptosis
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    9008-30-4
  • Formula Weight
    495.6
  • Molecular Formula
    C24H50NO7P (for palmitoyl)
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Methanol : 25 mg/mL (Ultrasonic)H2O : < 0.1 mg/mL (insoluble)DMSO
  • SMILES
    O[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COC([R])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim E A, et al. Lysophosphatidylcholine induces endothelial cell injury by nitric oxide production through oxidative stress [J]. The Journal of Maternal-Fetal & Neonatal Medicine, 2009, 22(4): 325-331.?
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