3-Sialyllactose sodium

Research use only, not for human use.

3'-Sialyllactose sodium is a prebiotic with anti-inflammatory activity that maintains immune homeostasis. 3'-Sialyllactose sodium reduces stressor-induced anxiety-like behaviors and can be used in studies of inflammation and arthritis.

3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation.

3'-Sialyllactose sodium (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines.3'-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes.3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation.3'-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation. Western Blot Analysis Cell Line:Chondrocytes Concentration:0, 50, 100 and 250 μM Incubation Time:24-36 hours Result:Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.

3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis.3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice.3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs.3'-Sialyllactose sodium shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested.Animal Model:8-week-old male C57BL/6 mice with medial meniscus surgery Dosage:10, 50 and 100 mg/kg Administration:Oral gavage; 10-100 mg/kg three times a week; for 6 weeks Result:Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.

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Apoptosis

NF-κB

NF-κB

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128596-80-5

655.53

C23H38NNaO19

>98% (HPLC)

In Vitro:?H2O : 250 mg/mL (381.37 mM; Ultrasonic)

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(-20℃)

With Ice Pack

≥ 2 years