LDN-193189 2HCl
CAS No. 1435934-00-1
LDN-193189 2HCl( —— )
Catalog No. M34754 CAS No. 1435934-00-1
LDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 68 | In Stock |
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| 5MG | 64 | In Stock |
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| 10MG | 83 | In Stock |
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| 25MG | 141 | In Stock |
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| 50MG | 220 | In Stock |
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| 100MG | 328 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | 778 | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameLDN-193189 2HCl
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NoteResearch use only, not for human use.
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Brief DescriptionLDN-193189 2HCl (DM-3189 2HCl) is a selective BMP signaling inhibitor that inhibits ALK1,ALK2,ALK3 and ALK6, showing IC50s of 0.8 nM, 0.8 nM, 5.3 nM, and 16.7 nM, respectively, in kinase assays.
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DescriptionLDN-193189 (dihydrochloride) is a potent selective BMP type I receptor (BMP I) inhibitor. LDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 can be used for the research of bone morphogenetic protein signalling, such as fibrodysplasia ossificans progressiva.
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In VitroLDN-193189 efficiently inhibits transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 values of 5 nM and 30 nM, respectively. LDN-193189 has weake effects on activin and the TGF-β type I receptors ALK4, ALK5 and ALK7 with IC50 values of ≥ 500 nM.LDN-193189 binds ActRIIA with Kd value of 14 nM.LDN-193189 (0.5 μM; 30 min) targets GDF8 induced Smad2/3 signaling and repression of myogenic transcription factors.LDN-193189 (0.05, 0.5, 5 μM) efficiently inhibits GDF8 induced Smad3/4 reporter gene activity.LDN-193189 (0-5 μM) rescues myogenesis in myoblasts treated with GDF8.
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In VivoLDN-193189 (i.p.; 3 mg/kg; daily; for 35 days) might affect the interaction between breast cancer cells and the bone environment.LDN-193189 (i.p.; 3 mg/kg; single) shows a reduction in ectopic ossification and functional impairment.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorTGF-beta/Smad | ALK
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Research Area——
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Indication——
Chemical Information
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CAS Number1435934-00-1
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Formula Weight479.4
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Molecular FormulaC25H24Cl2N6
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 11.11 mg/mL (23.17 mM; Ultrasonic)DMSO : 10 mg/mL (20.86 mM; Ultrasonic (<60°C)
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SMILESC1(C2=C3N=CC(C4=CC=C(N5CCNCC5)C=C4)=CN3N=C2)=C6C=CC=CC6=NC=C1.Cl.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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