ST-1006( —— )

Catalog No. M34715 CAS No. 1196994-11-2

ST-1006, a potent histamine H4 receptor agonist (pKi: 7.94), exhibits significant anti-inflammatory and anti-pruritic effects. It is also a potent inducer of basophil migration.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

ST-1006
Note

Research use only, not for human use.
Brief Description

ST-1006, a potent histamine H4 receptor agonist (pKi: 7.94), exhibits significant anti-inflammatory and anti-pruritic effects. It is also a potent inducer of basophil migration.
Description

ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect.
In Vitro

——
In Vivo

Animal Model:Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)Dosage:1-100 mg/kg Administration:Subcutaneous injection Result:Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
Synonyms

——
Pathway

GPCR/G Protein
Target

Histamine Receptor
Recptor

Histamine Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

1196994-11-2
Formula Weight

367.28
Molecular Formula

C16H20Cl2N6
Purity

>98% (HPLC)
Solubility

——
SMILES

N(CC1=C(Cl)C=CC=C1Cl)C2=CC(N3CCN(C)CC3)=NC(N)=N2
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397.?

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