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ST-1006

CAS No. 1196994-11-2

ST-1006( —— )

Catalog No. M34715 CAS No. 1196994-11-2

ST-1006, a potent histamine H4 receptor agonist (pKi: 7.94), exhibits significant anti-inflammatory and anti-pruritic effects. It is also a potent inducer of basophil migration.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 471 Get Quote
10MG 755 Get Quote
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Biological Information

  • Product Name
    ST-1006
  • Note
    Research use only, not for human use.
  • Brief Description
    ST-1006, a potent histamine H4 receptor agonist (pKi: 7.94), exhibits significant anti-inflammatory and anti-pruritic effects. It is also a potent inducer of basophil migration.
  • Description
    ST-1006 is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 has anti-inflammatory effect.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)Dosage:1-100 mg/kg Administration:Subcutaneous injection Result:Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Histamine Receptor
  • Recptor
    Histamine Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1196994-11-2
  • Formula Weight
    367.28
  • Molecular Formula
    C16H20Cl2N6
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(CC1=C(Cl)C=CC=C1Cl)C2=CC(N3CCN(C)CC3)=NC(N)=N2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Adami M, et, al. Differential effects of functionally different histamine H4 receptor ligands on acute irritant dermatitis in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Dec;391(12):1387-1397.?
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