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VU0422288
CAS No. 1630936-95-6
VU0422288( —— )
Catalog No. M34470 CAS No. 1630936-95-6
VU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 69 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 235 | In Stock |
|
| 50MG | 368 | In Stock |
|
| 100MG | 600 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1237 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameVU0422288
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NoteResearch use only, not for human use.
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Brief DescriptionVU0422288 (ML396) is a potent orthosteric modulator of type III mGlu receptors (mGlus).VU0422288 shows inhibition of mGluR4, mGluR7, and mGluR8 in a calcium mobilization assay.
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DescriptionVU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayNeuroscience
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TargetGluR
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RecptorGluR
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Research Area——
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Indication——
Chemical Information
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CAS Number1630936-95-6
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Formula Weight360.19
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Molecular FormulaC17H11Cl2N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 25 mg/mL (69.41 mM; Ultrasonic )
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SMILESClc1ccc(Oc2ccc(NC(=O)c3ccccn3)cc2Cl)nc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. ?
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