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VA-K-14 hydrochloride

CAS No. 1171341-19-7

VA-K-14 hydrochloride( —— )

Catalog No. M34462 CAS No. 1171341-19-7

VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 121 Get Quote
10MG 186 Get Quote
25MG 364 Get Quote
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Biological Information

  • Product Name
    VA-K-14 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    VA-K-14 hydrochloride（VAK14 HCl） is a selective thyrotropin receptor (TSHR) antagonist (IC50= 12.3 μM) that inhibits TSHR stimulation by serum and monoclonal TSHR-stimulating antibodies from patients with GD and abrogates TSHR signaling.
  • Description
    VA-K-14 hydrochloride is a specific thyroid-stimulating hormone receptor (TSHR) antagonist (IC50= 12.3 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    TSH Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1171341-19-7
  • Formula Weight
    341.86
  • Molecular Formula
    C18H16ClN3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 50 mg/mL (146.26 mM; Ultrasonic )
  • SMILES
    Cl.CNc1nc(cs1)-c1c([nH]c2ccccc12)-c1ccccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Latif R, et al. TSH Receptor Signaling Abrogation by a Novel Small Molecule. Front Endocrinol (Lausanne). 2016;7:130. Published 2016 Sep 27. ?
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