Cart
sales@molnova.com
TDRL-551
CAS No. 1644626-43-6
TDRL-551( —— )
Catalog No. M34443 CAS No. 1644626-43-6
TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 μM) with potential anticancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 223 | In Stock |
|
| 5MG | 202 | In Stock |
|
| 10MG | 297 | In Stock |
|
| 25MG | 630 | In Stock |
|
| 50MG | 986 | In Stock |
|
| 100MG | 1609 | In Stock |
|
| 200MG | 2167 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTDRL-551
-
NoteResearch use only, not for human use.
-
Brief DescriptionTDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 μM) with potential anticancer activity.
-
DescriptionTDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 μM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorOthers
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1644626-43-6
-
Formula Weight591.83
-
Molecular FormulaC25H23ClIN3O4
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 62.5 mg/mL (105.60 mM; Ultrasonic )
-
SMILESCCOc1ccc2cc(C3CC(=NN3C(=O)CCCC(O)=O)c3ccc(I)cc3)c(Cl)nc2c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33. ?
molnova catalog
related products
-
[Met2]-Deltorphin
[Met2]-Deltorphin
-
Alkyne tyramide
Alkyne tyramide is a clickable ascorbate peroxidase 2 (APEX2) probe which enable biotin-independent detection of labeled proteins.
-
BNTA
BNTA is a potent extracellular matrix (ECM) modulator. In a rat model of arthritis, BNTA modulates arthritis by promoting the synthesis of cartilage structural molecules on chondrocytes through the induction of superoxide dismutase 3 (SOD3) and regulating chondrogenesis through superoxide anion elimination.
